In the whole series, the median survival was 3.3 months. Patients with type 1 HRS not only had more severe liver and renal failure than type 2 patients, they also had greater impairment of circulatory function, as indicated by lower arterial pressure and higher activation of vasoconstrictor factors. Forty-one patients had type 1 HRS, while 64 patients had type 2 HRS. The study included 105 consecutive patients with HRS. The current study was designed to assess the prognostic factors and outcome of patients with cirrhosis and HRS. Moreover, the prognostic value of the model of end-stage liver disease (MELD) score has not been validated in the setting of HRS. However, scant information exists about factors predicting outcome in patients with cirrhosis and HRS. Conversely, multivariate analysis of these five factors in patients with MELD scores 20-29 found that age ( P = 0.012), etiology ( P = 0.024), serum sodium ( P = 0.005) and ascites ( P = 0.017) were independent predictors of 3-month mortality MELD score was not an independent predictor of mortality in patients with MELD score 20-29 once other factors were taken into account.Important progress has been made recently regarding the pathogenesis and treatment of hepatorenal syndrome (HRS). Of these five factors, only MELD score ( P = 0.015) was independent predictor of 3-month mortality in patients with MELD score ≥30. When the remaining predictors significant at P < 0.05 were subjected to binary logistic regression, only age ( P = 0.013), etiology ( P = 0.009), serum sodium ( P = 0.026), ascites ( P = 0.025), and MELD score ( P = 0.025) were independent predictors of 3-month mortality in all patients ( Table 6 ). In multivariate analyses to identify predictors of 3-month mortality ( Table 5 ), the significant factors (sex, age, etiology, serum sodium, ascites, MELD score) were entered in multivariate logistic regression model. Prognostic factors associated with 3-month mortality in multivariate analysis. Univariate analysis showed that the mortality of patients with MELD score ≥40 did not seem to be associated with sex ( P = 0.846), age ( P = 0.743), etiology ( P = 0.851), serum sodium ( P = 0.901) or ascites ( P = 0.517). In univariate analysis, we analyzed the prognostic value of clinical and biological variables in 3-month mortality of patients with MELD score ≥40 ( Table 4 ). Univariate prognostic analysis of the 3-month mortality of patients with MELD score ≥40. The mortality of patients with MELD score 30-39 did not seem to be associated with sex ( P = 0.897), serum sodium ( P = 0.236) or ascites ( P = 0.396). Univariate analysis showed that the following factors had significant prognostic value: age ( P = 0.046), and etiology ( P = 0.042). In univariate analysis, we analyzed the prognostic value of clinical and biological variables in 3-month mortality of patients with MELD score 30-39 ( Table 3 ). Univariate prognostic analysis of the 3-month mortality of patients with MELD score 30-39. The mortality of patients with MELD score 20-29 did not seem to be associated with sex ( P = 0.973). Univariate analysis showed that the following factors had significant prognostic value: age ( P = 0.047), etiology ( P = 0.039), serum sodium ( P = 0.029) and ascites ( P = 0.031). In univariate analysis, we analyzed the prognostic value of clinical and biological variables in 3-month mortality of patients with MELD score 20-29 ( Table 2 ). Univariate prognostic analysis of the 3-month mortality of patients with MELD score 20-29. Factors Influencing the Prediction Ability of MELD Scoring System